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菊粉如何通过菌群促进2型炎症？菊粉；膳食纤维；二型炎症

2022-11-08

美国康奈尔大学David Artis, Frank C. Schroeder和郭春君作为共同通讯作者的研究，发现富含可发酵纤维菊粉的饮食可以改变小鼠肠道菌群的组成和代谢，导致胆酸等胆汁酸水平升高，促进以嗜酸性粒细胞升高为特征的黏膜2型炎症反应，从而加剧过敏并增强抗寄生虫免疫。这些发现阐释了膳食纤维如何通过肠道菌群代谢物来发挥免疫调控作用的新机制，也揭示了膳食纤维-菌群-宿主免疫之间相互作用的复杂和多面性。

菊粉膳食纤维二型炎症
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Prebiotics, immune function, infection and inflammation: a review of the evidence b2-1 Fructans；Inulin；Oligofructose；Fructo-oligosaccharides；Cytokines

2022-10-09

β2-1 Fructans are carbohydrate molecules with prebiotic properties. Through resistance to digestion in the upper gastrointestinal tract, they reach the colon intact, where they selectively stimulate the growth and/or activity of beneficial members of the gut microbiota. Through this modification of the intestinal microbiota, and by additional mechanisms, β2-1 fructans may have beneficial effects upon immune function, ability to combat infection, and inflammatory processes and conditions. In this paper, we have collated, summarised and evaluated studies investigating these areas.

β2-1 Fructans Inulin Oligofructose Fructo-oligosaccharides Cytokines
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Inulin-type β2-1 fructans have some effect on the antibody response to seasonal influenza vaccination in healthy middle-aged humans prebiotic, oligofructose, immune response, vaccination, antibodies

2022-08-10

β2-1 fructans are prebiotics and, as such, may modulate some aspects of immune function. Improved immune function could enhance the host’s ability to respond to infections. There is limited information on the effects of β2-1 fructans on immune responses in humans. The objective of the study was to determine the effect of a specific combination of long-chain inulin and oligofructose (Orafti® Synergy1) on immune function in middle-aged humans, with the primary outcome being response to seasonal influenza vaccination.

prebiotic oligofructose immune response vaccination antibodies
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Inulin-enriched pasta improves intestinal permeability and modifies the circulating levels of zonulin and glucagon-like peptide 2 in healthy young volunteers Glucagon-like peptide 2； Intestinal permeability Inulin；Zonulin； Human

2022-08-10

Apart from the intestinal environment, inulin induces physiological effects, which includes a reduction in glucose and lipid concentrations and modulation of gastrointestinal motility through the release of different peptides. We hypothesized that inulin-enriched pasta may also improve small intestine permeability in relation to zonulin and glucagon-like peptide 2 (GLP-2) levels in healthy young subjects. Twenty healthy, young male volunteers completed a randomized, double-blind crossover study consisting of a 2-week run-in period and two 5- week study periods (11% inulin-enriched or control pasta), with an 8-week washout period in between.

Glucagon-like peptide 2 Intestinal permeability Inulin Zonulin Human
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Influence of prebiotics and antioxidants in bread on the immune system, antioxidative status and antioxidative capacity in male smokers and non-smokers Prebiotics: Green tea: Tomato paste: Antioxidant capacity: Smokers

2022-08-10

Interest in functional foods is increasing. The aim of the present study was to investigate breads supplemented with functional components. One was bread supplemented with inulin, linseed and soya fibre (prebiotic bread). The other was a prebiotic antioxidant bread (pre-aox-bread), which additionally contained green tea powder, herbs and tomato paste. The effects of these two breads on immunological and antioxidative parameters were compared with control bread (placebo).

Prebiotics Green tea Tomato paste Antioxidant capacity Smokers
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