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A Combination of Prebiotic Inulin and Oligofructose Improve Some of Cardiovascular Disease Risk Factors in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial MDA; Antioxidants; Lipid profile; Prebiotic; Type 2 diabetes

2023-11-10

This trial was conducted to evaluate the effects of oligofructose-enriched inulin on some of cardiovascular disease risk factors in women with type 2 diabetes. This clinical trial, showed that the oligofructose-enriched inulin supplementation for 8 weeks in diabetic patients decreased significantly body weight, BMI, the levels of FPG, HbA1c, TC, LDL-c, TC/ HDL-c ratio, LDLc/HDL-c ratio and MDA.

MDA Antioxidants Lipid profile Prebiotic Type 2 diabetes
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Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans Inulin; Triacylglycerol; Lipogenesis

2023-10-27

The objective was to determine whether the addition of a moderate dose of inulin to a moderately high-carbohydrate diet would decrease hepatic lipogenesis and plasma triacylglycerol concentrations and have a cholesterol-lowering action. The addition of high-performance inulin to a moderately high-carbohydrate, low-fat diet has a beneficial effect on plasma lipids by decreasing hepatic lipogenesis and plasma triacylglycerol concentrations. These results support the use of non-digestible carbohydrate for reducing risk factors for atherosclerosis.

Inulin Triacylglycerol Lipogenesis
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Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid Dietary inulin; NASH; Parabacteroides distasonis

2023-08-11

Non-alcoholic steatohepatitis (NASH) is the severe form of non-alcoholic fatty liver disease, and is characterized by liver inflammation and fat accumulation. Integration of C13-inulin metagenomes and metabolomes suggested that P.distasonis used inulin to produce pentadecanoic acid, an odd-chain fatty acid, which was confirmed in vitro and in germ-free mice. P. distasonis or pentadecanoic acid was protective against NASH in mice. Mechanistically, inulin, P. distasonis or pentadecanoic acid restored gut barrier function in NASH models, which reduced serum lipopolysaccharide and liver pro-inflammatory cytokine expression.

Dietary inulin NASH Parabacteroides distasonis
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Dietary Fructans and Serum Triacylglycerols: A Meta-Analysis of Randomized Controlled Trials Inulin-type Fructan; Serum Triacylglycerols; Blood Lipid

2023-03-24

We conducted a meta-analysis of available literature to quantify the effects in humans of dietary inulin-type fructans on serum triacylglycerols. In conclusion, dietary inulin-type fructans significantly reduced serum triacylglycerols. The mechanisms, possibly related to colonic fermentation and/or incretin release from the distal gut, warrant further studies.

Inulin-type Fructan Serum Triacylglycerols Blood Lipid
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Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans Inulin, stable isotopes, cholesterol, adipose tissue, SREBP-1c

2022-09-05

The objective was to determine whether the addition of a moderate dose of inulin to a moderately high-carbohydrate diet would decrease hepatic lipogenesis and plasma triacylglycerol concentrations and have a cholesterol-lowering action.

Inulin stable isotopes cholesterol adipose tissue SREBP-1c
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