Gut health

Inulin-Type Fructans in Healthy Aging Gut microbiota; Inulin; Healthy Aging; Gut health;

2023-05-11

Recent studies have shown that the gut microbiota changes in old age, with an increased number of bacterial groups represented in the predominant elderly gut microbiota. Here, the application of prebiotics, especially the inulin-type fructans, and synbiotics (prebiotics combined with efficacious probiotic strains) will be discussed in terms of microbiota modulation and impact on disease risk in the aged population.

Gut microbiota Inulin Healthy aging Gut health
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The Bifidogenic Nature of Chicory Inulin and Its Hydrolysis Products Inulin; Oligofructose; Bifidobacteria; Bifidogenicity; Dose effect；Prebiotic

2023-04-10

Research data on the bifidogenic effect of β(2-1)fructans, which at present are commercialized in the U.S., Japan and Europe as food ingredients, are presented. In vitro fermentation of inulin revealed that molecules with a chain length (degree of polymerization or DP) >10 are fermented on average half as quickly as molecules with a DP<10. All β(2-1) fructans are bifidogenic and classified as biobiotics.

Inulin Oligofructose Bifidobacteria Bifidogenicity Dose effect Prebiotic
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Inulin-type fructans of longer degree of polymerization exert more pronounced in vitro prebiotic effects Gut microbiota; Realtime PCR; Inulin; Degree of polymerization

2023-04-07

We assessed to what extent fructans of different degrees of polymerization (DP) differ in their prebiotic effectiveness towards in vitro microbial communities from the proximal and distal colon. Inulin has more pronounced prebiotic effects than oligofructose towards both fermentation activity and bacterial community composition in the SHIME model.

Gut microbiota Realtime PCR Inulin Degree of polymerization
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An open label, non-randomized study assessing a prebiotic fiber intervention in a small cohort of PD participants Prebiotic fiber; Parkinson’s disease (PD); Intestinal microbiome

2023-03-23

A pro-inflammatory intestinal microbiome is characteristic of Parkinson's disease (PD). Prebiotic fibers change the microbiome and this study sought to understand the utility of prebiotic fibers for use in PD patients. This proof-of-concept study offers the scientific rationale for placebo-controlled trials using prebiotic fibers in PD patients.

Prebiotic fiber Parkinson's disease (PD) Intestinal microbiome
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Prebiotic inulin-type fructans induce specific changes in the human gut microbiota Inulin; Gut microbiota; Bilophila

2023-03-23

We apply 16S rDNA microbiota profiling and matching (gas chromatography mass spectrometry) metabolomics to assess the consequences of inulin fermentation both on the composition of the colon bacterial ecosystem and faecal metabolites profiles. Ecosystem-wide analysis of the effect of a dietary intervention with prebiotic inulin-type fructans on the colon microbiota revealed that this effect is specifically associated with three genera, one of which (Bilophila) representing a promising novel target for mechanistic research.

Inulin Gut microbiota Bilophila
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